Starting on an idea
If you've got an idea that might just work, then I suppose you'd like to get started drawing it. This is what I would usually do:
I would create a quick sketch of my idea, with stickman characters and rough drawings. I would double check the small sketch, and imagine I were a person that did not make it, viewing it. If I think it would make them laugh or giggle, I would get started on the big stuff.
First, I ruler out the boxes with a thin pencil like a 2H. Then, I would ruler out text lines at the top of every frame, even if in that frame no one was speaking. I would then right out the words that would be in the strip, and I would make sure that every same letter looks pretty much the same, or else the readers would get confused. Then, I would lightly pencil the characters and background in every frame.
Once I'm done with sketching everything in pencil, I would take out my waterproof pen felt tipped, and doesn't leak over the paper and go over the penciled words at the top of the frames. Then I would use the same pen to go over the characters and main stuff. Now we're almost done.
I then take out my thinner, trusty, stabilo pen, and line the background and add any missing details. Once that is done, I check for any mistakes and use my white-out pen to cover any. TADA, it's finished on paper.
I will then scan it into the computer and fill any shading places with black or greyscale.